000			01408nam a22001697a 4500
003			OSt
005			20221115095534.0
008			221115b ||||| |||| 00| 0 eng d
020			_a978-0-470-68934-9
040			_cLC
245			_aHuman Drug Metabolism: An Introduction, 2nd Edition _cMichael D. Coleman
250			_a2nd ed.
260			_bWiley, _c2010.
300			_a 360 Pages
520			_bHuman Drug Metabolism, An Introduction, Second Edition provides an accessible introduction to the subject and will be particularly invaluable to those who already have some understanding of the life sciences. Completely revised and updated throughout, the new edition focuses only on essential chemical detail and includes patient case histories to illustrate the clinical consequences of changes in drug metabolism and its impact on patient welfare. After underlining the relationship between efficacy, toxicity and drug concentration, the book then considers how metabolizing systems operate and how they impact upon drug concentration, both under drug pressure and during inhibition. Factors affecting drug metabolism, such as genetic polymorphisms, age and diet are discussed and how metabolism can lead to toxicity is explained. The book concludes with the role of drug metabolism in the commercial development of therapeutic agents as well as the pharmacology of some illicit drugs.
942			_2lcc _cBK
999			_c157896 _d157896